Genes and celiac disease

Authors

  • Nada Starčević Čizmarević Zavod za biologiju i medicinsku genetiku, Medicinski fakultet Sveučilišta u Rijeci, Braće Branchetta 20, 51000 Rijeka
  • Brankica Mijandrušić-Sinčić Interna klinika, Zavod za gastroenterologiju, Klinički bolnički centar Rijeka, Krešimirova 42, 51000 Rijeka
  • Vanja Licul Interna klinika, Zavod za gastroenterologiju, Klinički bolnički centar Rijeka, Krešimirova 42, 51000 Rijeka
  • Miljenko Kapović Zavod za biologiju i medicinsku genetiku, Medicinski fakultet Sveučilišta u Rijeci, Braće Branchetta 20, 51000 Rijeka
  • Smiljana Ristić Zavod za biologiju i medicinsku genetiku, Medicinski fakultet Sveučilišta u Rijeci, Braće Branchetta 20, 51000 Rijeka

DOI:

https://doi.org/10.13112/PC.2015.14

Keywords:

celiac disease, genetic predisposition to disease, genes, histocompatibility antigens

Abstract

Celiac disease is a chronic infl ammatory disease of the small intestine triggered by gluten intake, which occurs in genetically susceptible individuals. The purpose of this paper is to present recent fi ndings in the genetics of celiac disease. Genetic background of celiac disease related to human leukocyte antigen locus (HLA) as a dominant genetic element has been well described. However, the existence of a large number of non-HLA celiac disease genes, only partly shared by each individual patient, suggests genetic heterogeneity of the disease. In addition, it has been observed that many of these risk loci in celiac disease are common with the loci for other autoimmune diseases. A signifi cant contribution to our knowledge has been provided by recent genome-wide association studies, but great part of the still unknown heritability in celiac disease is yet to be explored in the future.

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Published

2015-06-30

Issue

Vol. 59 No. 2 (2015)

Section

Review

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

By publishing in Paediatria Croatica, authors retain the copyright to their work and grant others the right to use, reproduce, and share their research articles in accordance with the Creative Commons Attribution License (CC BY 4.0), which allows others to distribute and build upon the work as long as they credit the author for the original creation.

How to Cite

Čizmarević, N. S., Mijandrušić-Sinčić, B., Licul, V., Kapović, M., & Ristić, S. (2015). Genes and celiac disease. Paediatria Croatica, 59(2), 88-94. https://doi.org/10.13112/PC.2015.14

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