Urolithiasis – a potential complication of ceftriaxone therapy

Authors

  • Daniel Turudić Medicinski fakultet Sveučilišta u Zagrebu, 10000 Zagreb
  • Daniel Turudić Medicinski fakultet Sveučilišta u Zagrebu, 10000 Zagreb
  • Danica Batinić Medicinski fakultet Sveučilišta u Zagrebu, Klinički bolnički centar Zagreb, Zavod za nefrologiju, dijalizu i transplantaciju, 10000 Zagreb
  • Branko Miše Zavod za dječje zarazne bolesti, Sveučilište u Zagrebu, 10000 Zagreb
  • Ivan Habuš Odjel za fi zikalnu kemiju Instituta „Ruđer Bošković“, 10000 Zagreb
  • Marija Spajić Odjel za fi zikalnu kemiju Instituta „Ruđer Bošković“, 10000 Zagreb
  • Goran Krnjak Medicinski fakultet Sveučilišta u Zagrebu, Klinički bolnički centar Zagreb, Zavod za nefrologiju, dijalizu i transplantaciju, 10000 Zagreb
  • Danko Milošević Medicinski fakultet Sveučilišta u Zagrebu, Klinički bolnički centar Zagreb, Zavod za nefrologiju, dijalizu i transplantaciju, 10000 Zagreb

DOI:

https://doi.org/10.13112/PC.2014.3

Keywords:

Ceftriaxone, urinary calculi, urinary tract infections

Abstract

A cohort of 238 children diagnosed with cystopyelonephritis were retrospectively analyzed in 2011 to assess the possible ceftriaxone risk of urinary stone formation. All children were treated with ceftriaxone in a standard dosage of 60 mg/kg/day for 10 days. Urinary tract imaging revealed anomalies in 73, vesicoureteral refl ux in 66 and hydronephrosis in 7 children. No ceftriaxone stone formation and no sign of abdominal colic or macro/microhematuria was found during one-month monitoring. Ceftriaxone administration is quite safe in the usual dosage of 60 mg/kg/24 h for 10 days. Caution is only warranted in children requiring higher dosage of ≥100 mg/kg/24 h and prolonged administration. In such cases, we recommend ultrasound of urinary tract and gallbladder screening for hypercalciuria and alkalization of urine.

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Published

2014-03-30

Issue

Vol. 58 No. 1 (2014)

Section

Original Scientific Paper

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

By publishing in Paediatria Croatica, authors retain the copyright to their work and grant others the right to use, reproduce, and share their research articles in accordance with the Creative Commons Attribution License (CC BY 4.0), which allows others to distribute and build upon the work as long as they credit the author for the original creation.

How to Cite

Turudić, D., Turudić, D., Batinić, D., Miše, B., Habuš, I., Spajić, M., Krnjak, G., & Milošević, D. (2014). Urolithiasis – a potential complication of ceftriaxone therapy. Paediatria Croatica, 58(1), 15-17. https://doi.org/10.13112/PC.2014.3

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